 Eddie Sachs | Estados Unidos | 1927 | 0 | 1 | — | — |
 Bob Said | Estados Unidos | 1932 | 0 | 0 | — | — |
| Mike Salay | Estados Unidos | 1909 | 0 | 0 | — | — |
 Eliseo Salazar | Chile | 1954 | 0 | 0 | — | — |
| Francisco Godia Sales | España | 1921 | 0 | 0 | — | — |
 Mika Salo | Finlandia | 1966 | 0 | 0 | — | — |
 Roy Salvadori | Reino Unido | 1922 | 0 | 0 | — | Gilby Engineering, British Racing Motors, Vanwall |
 Consalvo Sanesi | Reino de Italia | 1911 | 0 | 0 | — | Alfa Romeo |
 Logan Sargeant | Estados Unidos | 2000 | 0 | 0 | — | — |
 Stéphane Sarrazin | Francia | 1975 | 0 | 0 | — | — |
 Takuma Satō | Japón | 1977 | 0 | 0 | — | — |
| Carl Scarborough | Estados Unidos | 1914 | 0 | 0 | — | — |
 Ludovico Scarfiotti | Italia | 1933 | 1 | 0 | — | — |
 Giorgio Scarlatti | Reino de Italia | 1921 | 0 | 0 | — | Scuderia Centro Sud, Cooper Car Company, Scuderia Serenissima |
 Ian Scheckter | Sudáfrica | 1947 | 0 | 0 | — | — |
 Jody Scheckter | Sudáfrica | 1950 | 10 | 3 | 1 | — |
 Harry Schell | Francia | 1921 | 0 | 0 | — | — |
 Tim Schenken | Australia | 1943 | 0 | 0 | — | Trojan-Tauranac Racing |
| Albert Scherrer | Suiza | 1908 | 0 | 0 | — | — |
 Domenico Schiattarella | Italia | 1967 | 0 | 0 | — | — |
 Heinz Schiller | Suiza | 1930 | 0 | 0 | — | — |
 Bill Schindler | Estados Unidos | 1909 | 0 | 0 | — | — |
 Jean-Louis Schlesser | Francia | 1948 | 0 | 0 | — | RAM Racing, Williams Racing |
 Jo Schlesser | Francia | 1928 | 0 | 0 | — | — |
 Bernd Schneider | Alemania | 1964 | 0 | 0 | — | — |
| Rudolf Schoeller | Suiza | 1902 | 0 | 0 | — | — |
| Rob Schroeder | Estados Unidos | 1926 | 0 | 0 | — | — |
 Michael Schumacher | Alemania | 1969 | 91 | 68 | 7 | Benetton Formula, Scuderia Ferrari, Mercedes |
 Mick Schumacher | Alemania | 1999 | 0 | 0 | — | Mercedes, Haas F1 Team |
 Ralf Schumacher | Alemania | 1975 | 6 | 6 | — | — |
 Vern Schuppan | Australia | 1943 | 1 | 0 | — | — |
 Bob Scott | Estados Unidos | 1928 | 0 | 0 | — | — |
 Piero Scotti | Reino de Italia | 1909 | 0 | 0 | — | — |
 Wolfgang Seidel | Alemania | 1926 | 0 | 0 | — | — |
 Ayrton Senna | Brasil | 1960 | 41 | 65 | 3 | McLaren, Toleman, Team Lotus |
 Bruno Senna | Brasil | 1983 | 0 | 0 | — | — |
 Dorino Serafini | Italia | 1909 | 0 | 0 | — | — |
 Chico Serra | Brasil | 1957 | 0 | 0 | — | Fittipaldi Automotive, Arrows Grand Prix International |
 Doug Serrurier | Sudáfrica | 1920 | 0 | 0 | — | — |
 Johnny Servoz-Gavin | Francia | 1942 | 0 | 0 | — | Tyrrell Racing, Cooper Car Company, Equipe Matra Sports |
| Tony Settember | Estados Unidos | 1926 | 0 | 0 | — | — |
| Doc Shanebrook | Estados Unidos | 1907 | 0 | 0 | — | — |
 Hap Sharp | Estados Unidos | 1928 | 0 | 0 | — | — |
| Brian Shawe-Taylor | Irlanda | 1915 | 0 | 0 | — | — |
 Carroll Shelby | Estados Unidos | 1923 | 0 | 0 | — | — |
| Tony Shelly | Estados Unidos | 1937 | 0 | 0 | — | — |
 Jo Siffert | Suiza | 1936 | 2 | 2 | — | Siffert Racing Team, March Engineering, British Racing Motors |
| Andre Simon | Francia | 1920 | 0 | 0 | — | Scuderia Centro Sud, Scuderia Ferrari, Mercedes |
 Serguéi Sirotkin | Rusia | 1995 | 0 | 0 | — | Williams Racing |
 Rob Slotemaker | Reino de los Países Bajos | 1929 | 0 | 0 | — | — |
 Alex Soler-Roig | España | 1931 | 0 | 0 | — | — |
 Raymond Sommer | Francia | 1906 | 0 | 1 | — | — |
| Joe Sostilio | Estados Unidos | 1915 | 0 | 0 | — | — |
 Mike Sparken | Francia | 1930 | 0 | 0 | — | — |
 Scott Speed | Estados Unidos | 1983 | 0 | 0 | — | — |
 Mike Spence | Reino Unido | 1936 | 1 | 0 | — | Reg Parnell Racing, Emeryson, Team Lotus |
 Alan Stacey | Reino Unido | 1933 | 0 | 0 | — | — |
 Gaetano Starrabba | Italia | 1932 | 0 | 0 | — | — |
| Gig Stephens | Estados Unidos | 1926 | 0 | 0 | — | — |
 Will Stevens | Reino Unido | 1991 | 0 | 0 | — | Caterham F1 Team |
 Chuck Stevenson | Estados Unidos | 1919 | 0 | 0 | — | — |
 Ian Stewart | Reino Unido | 1929 | 0 | 0 | — | — |
 Jackie Stewart | Reino Unido | 1939 | 27 | 17 | 3 | Equipe Matra Sports, British Racing Motors, Tyrrell Racing |
| Jimmy Stewart | Reino Unido | 1931 | 0 | 0 | — | — |
 Siegfried Stohr | Italia | 1952 | 0 | 0 | — | — |
 Rolf Stommelen | Alemania | 1943 | 0 | 1 | — | — |
| Mauritz von Strachwitz | Alemania | 1929 | 0 | 0 | — | — |
 Philippe Streiff | Francia | 1955 | 0 | 0 | — | — |
 Lance Stroll | Canadá | 1998 | 0 | 1 | — | Racing Point F1 Team |
 Hans Stuck | Alemania | 1900 | 0 | 0 | — | — |
 Hans-Joachim Stuck | Alemania | 1951 | 0 | 0 | — | — |
 Danny Sullivan | Estados Unidos | 1950 | 0 | 0 | — | — |
 Marc Surer | Suiza | 1951 | 0 | 0 | — | — |
 John Surtees | Reino Unido | 1934 | 6 | 8 | 1 | Scuderia Ferrari, Surtees, Cooper Car Company |
 Adrian Sutil | Alemania | 1983 | 0 | 0 | — | Spyker F1 Team, Force India, Sauber |
| Len Sutton | Estados Unidos | 1925 | 0 | 0 | — | — |
 Aguri Suzuki | Japón | 1960 | 0 | 0 | — | — |
 Toshio Suzuki | Japón | 1955 | 0 | 0 | — | — |
 Jacques Swaters | Bélgica | 1926 | 0 | 0 | — | — |
| Bob Sweikert | Estados Unidos | 1926 | 1 | 0 | — | — |